Osaka Municipal Museum of Art opened in May 1936. Although the museum is presently located inside Tennoji Park, the property used to belong to the Sumitomo family for their main house, and was later donated to the city of Osaka together with a garden (Keitaku-en) for the purpose of building a museum. The museum consists of the main building which was built at the time of foundation, and basement exhibit rooms that were built underground in front of the museum in 1992. It has three floors above ground and two floors underground, and special and regular exhibitions hosted by the museum are held in the exhibition galleries of the main building.

In the regular exhibitions, over 8,000 works of Japanese and Chinese paintings, sculptures, and decorative art that are collected through purchasing and donations, as well as articles entrusted by temples and shrines, can be seen at any time. Many of them are designated National Treasures and Important Cultural Properties. In the basement exhibit rooms, a number of exhibitions sponsored by various art organizations are held on a regular basis. The Art Academy is also located in the basement of the main building, which instructs techniques and skills in sketching, painting, and sculpture.